Effect of Epilepsy in Pregnancy a. Effects during pregnancy. Most pregnancies in women with epilepsy are normal and no abnormalities in the birth process. b. Effects on the Fetus. Effect of epilepsy and OAE in the fetus can be divided into changes in anthropometric, minor anomalies, major malformations, and physiological disorders and fetal death.
Specific syndrome associated with phenytoin-called fetal phenytoin syndrome. This syndrome is similar to fetal alcohol syndrome and consists of major congenital abnormalities in the form of microcephaly, stunted growth, impaired intellectual function and minor abnormalities in the form of strabismus, ptosis, hipertelorism in the eye, hipotonia, inguinal hernia and umbilikal, and deformity of the foot. These also can occur in the use of barbiturates and other antiepileptic drugs.
Been reported cases of neural tube defects associated with use of valproic. Similarly, cases of spina bifida, microcephaly, and anensefali, more common in the use of valproic. The use of carbamazepine also lead to spina bifida risk.
Effect on When Childbirth
Risk of difficulty when deliveries in patients with epilepsy is higher and the general population, such as obstructed labor prematurus. The use of OAE result in weakening of the uterine contractions and premature rupture of membranes. Giving vitamin K oral 10 mg / day dir.ekomendasikan minimum 1 month prior to delivery because there is an increased risk of bleeding in newborns because of the influence of the use of OAR